CLEANING TIPS
The Best Laundry Detergent for Pet Odors
Written by TEAM BLUELAND
Published: September 18, 2024
Updated: September 30, 2026


When it comes to stubborn odors, pet odors are often the worst of the worst. And that kind of odor situation requires a very particular solution: enzymes. Luckily, Blueland's Laundry Detergent Tablets are formulated for just that.
Why Pet Smell Doesn't Just Wash Out
A regular laundry cycle is built to handle dirt, oil, and everyday grime, but pet odor is a different kind of problem. Dog and cat urine leaves behind uric acid crystals that re-activate and smell whenever they get damp, saliva and drool carry proteins from a dog's mouth, and dander is made of shed skin cells. None of that is oil-based, so a detergent that only handles grease can leave the smell-causing proteins sitting in the fibers even after the fabric looks and feels clean.
That's also why the smell tends to come back after the load dries: heat from the dryer can set whatever protein residue is left, baking the odor in rather than removing it. If you keep washing pet bedding or a dog's favorite blanket and the smell keeps returning, the detergent is usually the problem.
What Enzymes Actually Do to Pet Odor
Enzymes are proteins themselves, and the ones used in laundry detergent work like molecular scissors. According to research from the University of Maryland's chemical engineering department, protease cuts the peptide bonds holding a protein together, breaking it down into smaller water-soluble amino acid pieces that rinse out instead of clinging to the fabric. Since pet odor is largely protein, protease does most of the actual work. Other common laundry enzymes like amylase (starches) and lipase (fats) matter for food and grease stains, but protease is the one aimed at urine, saliva, and dander specifically. (For a fuller breakdown of how these formulas work in general, check out our guide to how enzyme laundry detergent works.)
One useful side effect: enzymes are engineered to work in the cooler, less alkaline conditions of a normal wash, which is why enzyme-based detergents don't need hot water to be effective. Cold-water washing also happens to be better for the planet and uses a fraction of the energy of a hot cycle.
What to Look for in a Pet-Odor Detergent
Not every detergent is built the same way, so a few things are worth checking before you buy one specifically for pet smell:
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Enzymes on the ingredient list. Look for protease specifically, since that's the one that targets protein-based odor. If a label just says "odor-fighting" without naming what's doing the fighting, be skeptical.
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A full-strength dose for the load. Pet bedding and heavily soiled towels usually need the regular or "heavy soil" amount, not a lighter setting meant for everyday laundry.
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No added fabric softener in the formula. Softener works by coating fibers, which can trap odor-causing residue underneath rather than letting the wash rinse it away.
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A formula you can actually see the ingredients for. Since "non-toxic" and "natural" aren't claims a laundry detergent can make without specific backing, look instead for a full, disclosed ingredient list and a real certification. Blueland's formulas are EPA Safer Choice certified, which means the ingredients meet the EPA's criteria for safer chemistry.
A Wash Routine That Actually Works
The detergent matters, but how you use it matters almost as much:
1. Shake or vacuum off loose hair and dander first. It keeps your machine's filter and drain from doing double duty.
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Use a full cycle, not a quick or eco setting. Enzymes need contact time with the fabric to fully break down protein, so a 15-minute quick wash often isn't long enough.
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Wash in cold or warm water, not hot, so the enzymes stay active and you're not risking a set-in stain.
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Skip the dryer sheet and fabric softener on anything that's held onto pet smell before.
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Add an oxygen booster for anything musty or set-in. A product like Blueland's Oxi Laundry Booster works alongside the detergent's enzymes rather than replacing them, and it's especially useful on bedding that's been smelly for weeks rather than days.
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Air-dry when you can, at least the first time. If any odor is left, a dryer's heat can set it before you get a chance to notice and rewash.
Pet Beds, Blankets, and Towels Need Their Own Rules
Clothes that brush up against a pet are one thing; a dog bed, crate pad, or the blanket a cat sleeps on all day is another. Those items hold a much higher concentration of dander, saliva, and skin oil, and they don't get the benefit of being worn and washed as often as clothing.
Pet dander in particular is a common trigger for allergy symptoms. Sneezing, congestion, and eye irritation are typical reactions, and dander can also trigger asthma in people who have it, according to the American Lung Association. It's also persistent: allergists note that even after a pet is removed from a home entirely, it can take up to six months for all of the dander in fabric and carpet to clear out, according to the Asthma and Allergy Foundation of America. That's a good reason to wash pet bedding weekly rather than waiting until it visibly needs it, and to use the same enzyme-based approach on it that you'd use on urine or drool stains, since dander is protein too.
When It's More Than a Detergent Problem
If a smell keeps coming back no matter what detergent you use, the fabric itself may have absorbed more than a wash cycle can pull out. This happens most with foam-filled pet beds, which soak up urine and don't rinse clean the way woven fabric does. In that case, a pre-soak with an oxygen booster before the main wash on the machine’s largest water setting gives the enzymes more time and more water to work with. Some pet beds with a removable, machine-washable cover but a foam insert that isn't washable may need to be replaced entirely if the odor has soaked all the way through.
Common Questions
Does hot water actually work better than cold water on pet smell?
No, enzyme-based detergents are built to work in cold or warm water, and hot water can set certain stains or damage delicate pet bedding. Cold water is the safer default for pet-related laundry.
Can I use the same detergent on my dog's bed that I use on my own laundry?
Yes, as long as it's enzyme-based and the bed's care label allows machine washing. Just use the full or heavy-soil dose rather than a light one, since pet bedding usually needs it.
Why does my laundry smell like pet again after it comes out of the dryer?
That usually means some odor-causing protein was still in the fabric when it went into the dryer, and the heat set it rather than removing it. Try air-drying the load the next time to check whether the smell is actually gone before adding heat.
Is enzyme detergent safe for pets that will be sleeping on the washed bedding?
Enzyme-based detergents are widely used in pet bedding and pet-specific laundry products precisely because they're effective at breaking down the same organic residue pets produce. Rinsing on a full cycle and avoiding fragrance-heavy additives is the main thing to watch for if a pet has sensitive skin.
Sources
Enzymes in Laundry Detergents, University of Maryland
Pet Dander, American Lung Association
How Do We Remove Cat Dander from a Home?, Asthma and Allergy Foundation of America
Safer Choice Criteria for Enzymes and Enzyme Stabilizers, U.S. Environmental Protection Agency
Key Takeaways
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Pet odor is mostly protein so it takes an enzyme-based detergent to break it down, not just soap and fragrance to cover it up.
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Enzymes like protease work in cold water, so you don't need a hot wash to get pet smell out (cold water is also gentler on fabric and uses a lot less energy).
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For bedding or towels that have been holding onto odor for a while, Blueland's Oxi Laundry Booster added alongside an enzyme detergent gives the wash extra backup.
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